Synthesis And Anticonvulsant Activity Of Some Substituted 3,5-Diphenyl-2-Pyrazoline-1-Carboxamide Derivatives

Abstract

Some substituted 3,5-diphenyl-2-pyrazoline-1-carboxamide derivatives were synthesized from appropriate substituted 1,3-diphenylprop-2-en-1-one (chalcone) on reaction with semicarbazide hydrochloride. The final compounds were structurally elucidated on the basis of IR, 1H-NMR & mass spectral data and microanalyses. The final compounds were evaluated for anticonvulsant activity by the maximal electroshock seizure (MES) method. The neurotoxicity was determined by rotorod toxicity test on male albino mice. The preliminary results showed that all of the tested compounds were protective against MES at 100-300 mg/kg dose levels. The compounds numbered 4d-4e, 4j-4k, and 4m-4t were most protective against MES even at 30 mg/kg dose levels.