Abstract
AbstractA number of novel 3‐aminoquinazolines were obtained via two synthetic pathways. In the first method o‐aminobenzoylhydrazines were prepared either by reacting an isatoic anhydride and a hydrazine or by reacting o‐nitrobenzoic acid with a hydrazine, followed by catalytic reduction. Subsequent cyclization with an appropriate orthoester provided 3‐aminoquinazolines and 2‐methyl‐3‐aminoquinazolines. The second pathway involved condensation of o‐aminoacetophenone with a hydrazine to form hydrazones which were reduced to aminohydrazines and cyclized as above to yield 4‐methyl‐3‐aminoquinazolines and 2,4‐dimethyl‐3‐aminoquinazolines. The title compounds were evaluated in mice in MES and sc Met seizure models for anticonvulsant activity, and in the rotorod test for neurotoxicity. They were generally toxic. However, 4‐methyl‐3‐(N‐piperidino)‐3,4‐dihydroquinazoline hydrochloride exhibited activity comparable to that of methaqualone.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
