Abstract
A new series of 4-(2-phenoxyphenyl)semicarbazones were synthesized as potential anticonvulsant agents. Thus, the reaction of 4-(2-phenoxyphenyl)semicarbazide with various benzaldehydes and acetophenones in ethanol yielded the corresponding semicarbazones 6a–k and 7a–i, respectively. Structures of the synthesized compounds were confirmed by spectral data and elemental analysis. All compounds were evaluated for their anticonvulsant activity in pentylenetetrazole (PTZ)-induced kindling model in adult male Wistar rats. The neurotoxicity of active compounds was also assessed using the rotorod method. The results showed that two compounds (6g and 6i) showed greater protection from seizure than sodium valproate at dose of 100 mg/kg. Compounds 6g and 6i showed no neurotoxicity at the maximum dose administered (300 mg/kg).
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