Abstract
2-(Dimethylamino)ethyl esters of a number of N-substituted α-amino acids and their quaternary ammonium salts were synthesized and their physiochemical properties were determined. We report here studies of their interactions with erythrocyte acetylcholinesterase and human plasma butyrylcholinesterase. IC50 values (the concentrations of study compounds producing 50% inhibition of the rate of cholinesterase hydrolysis of 0.1 mM acetylcholine) were measured for all the compounds synthesized. The results showed that all the choline esters of N-substituted amino acids synthesized here had anticholinesterase properties, mainly specific for butyrylcholinesterase.
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