Synthesis and anticancer property of Zn(II) compounds nanoparticles based on tetrazole carboxylate ligands

Abstract

Two new coordination compounds, [Zn(pytzipa)2(H2O)4]·2H2O (1) and [Zn2(dtzpda)(H2O)5]·3H2O (2) have been synthesized by solvothermal reactions of Zn(NO3)2·6H2O with Hpytzipa or H4dtzpda, respectively (Hpytzipa = 5-(3-pyridyl)tetrazole-2-isoproponaic acid, H4dtzpda = 3,3-di(1H-tetrazol-5-yl)pentanedioic acid). The X-ray diffraction results reveal that compound 1 is a linear chain in which pytzipa acts as a bidentate ligand to bridge adjacent Zn2+ ions by the nitrogen atom of the pyridine ring and the oxygen atom of the carboxylate group. In compound 2, dtzpda4− acts as a hepta-dentate ligand to bridge adjacent Zn2+ ions by the nitrogen atoms of the tetrazole rings and the oxygen atoms of the carboxylate in a chelating mode. Furthermore, nanoparticles (NPs) of the two compounds were prepared by co-precipitation with PEG-5000(poly(ethyleneglycol-5000)). Both two NPs show considerable cytotoxicity towards HeLa cells but Hpytzipa and H4dtzpda are non-toxic in nature. The results show that coordination Zn(II) with Hpytzipa or H4dtzpda can improve the toxicity of the NPs significantly and the NPs of the compounds are potential candidates for treatment of cancer cells.