Abstract
An antifouling active natural compound, 3-isocyanotheonellin, and its analogues were synthesized and evaluated for antifouling activity against the larvae of the barnacle Balanus amphirite in order to explore structure-activity relationships. The anti-barnacle effect of the 3-isocyanotheonellin analogues was in the EC 50 range 0.18-7.20 w g ml m 1 . Some synthesized analogues exhibited potent antifouling activity as high as 3-isocyanothoenllin, and none of the synthesized isocyano compounds showed significant toxicity. The results of the present study suggest that an isocyano group and a hydrophobic site at a suitable position are important for potent antifouling activity without toxicity.
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