Abstract

Ten new chalcones were prepared in three steps, firstly phthalic anhydride reacted with 4- amino acetophenone to produce 2-(4-acetyl phenyl carbamoyl) benzoic acid (A1), secondly [2-(4-acetyl phenyl carbamoyl) benzoic acid (A1)] suffers from the loss of a water molecule via reaction with (anhydrous sodium acetate and acetic anhydride) to produce 2-(4-acetyl phenyl) isoindoline-1,3-dione (A2), thirdly this compound condensed with various substituted benzaldehydes affording chalcones (A3- A12) were reacted with hydrazine hydrate to produce pyrazole compounds (A13- A22). The prepared compounds were characterized by determination of melting point, FT-IR and some of the prepared compounds have been characterized by (1 H-NMR and 13C-NMR) techniques.

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