Abstract
A series of quaternary ammonium derivatives of triazolyl pyranochromen-2-ones have been synthesized and characterized; their antibacterial potential were investigated against two gram negative (Pseudomonas aeruginosa and Escherichia coli) and two gram positive bacterial strains (Bacillus cereus and Staphylococcus aureus). In order to develop structure-activity relationship (SAR), the effect of varying the substituent (R) at the C-10 position of pyranochromen-2-one as well as the length of the spacer (n) between the triazolyl pyranochromen-2-ones and quaternary ammonium group, on the antibacterial activity of compounds has been evaluated. Some of the screened compounds exhibited antibacterial potential against the studied strains in the microgram range. A series of quaternary ammonium derivatives of triazolyl pyranochromen-2-ones have been synthesized, characterized AND their antibacterial potential investigated. In order to develop structure-activity relationship (SAR), the effect of varying the substituent (R) at the C-10 position of pyranochromen-2-one as well as the length of the spacer (n) between the triazolyl pyranochromen-2-ones and quaternary ammonium group, on the antibacterial activity of compounds has been evaluated.
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