Abstract
A series of substituted 1,2,3,4-tetrahydropyrazino [1,2- a] indole derivatives have been synthesized and tested against the Gram positive and Gram negative strains of bacteria namely Staphylococcus aureus (MTCCB 737), Salmonella typhi (MTCCB 733), Pseudomonas aeruginosa (MTCCB 741), Streptomyces thermonitrificans (MTCCB 1824) and Escherichia coli (MTCCB 1652). All synthesized compounds showed mild to moderate activity. However, compounds 4d– f were found to have potent activity against pathogenic bacteria used in the study. Their MIC ranged from 3.75 to 60 μg/disc. In vitro toxicity tests demonstrated that toxicity of 4d– f was not significantly different than that of gentamycin. However, at higher concentration (1000–4000 μg/ml) difference was highly significant.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
