Synthesis and Antibacterial Activity of Novel N-Methyl Pyrrolidine Dendrimers via [3+2] Cycloaddition

Abstract

One-pot synthesis of novel N-methyl pyrrolidine dendrimers has been accomplished in good yield via a facile [3+2] cycloaddition of azomethine ylide with chalcone moiety of the dendrimer as a dipolarophile. All the pyrrolidine dendrimers exhibited moderate and comparable antibacterial activity as that of the standard viz., chloramphenicol against Bacillus subtilis, E. coli, Klebsiella pneumoniae and species of Streptococcus by agar well diffusion method.