Abstract
New spiro-isoquinolinones have been efficiently synthesised by the condensation of secondary N-allylamines and 2-bromobenzoyl chloride, followed by a sequential procedure involving an intramolecular Heck reaction and 1,3-dipolar cycloaddition. The regiospecificity of the reaction was established by mono and two-dimensional NMR analysis. The spiro-compounds were evaluated for their antibacterial activity against some strains of bacteria using the disc diffusion method and micro-dilution tests.
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