Synthesis and anti-inflammatory evaluation of novel thiadiazol derivatives of Mefenamic acid

A Ahmadi

doi:10.4314/bcse.v31i1.15

Abstract

In the search for new potential non-steroidal anti-inflammatory agents, some novel Mefenamic acid derivatives were synthesized and confirmed by spectroscopic data. The anti-inflammatory activities of these compounds were evaluated by the croton oil-induced ear oedema test in mice. The preliminary pharmacological evaluations indicate that these new compounds showed potent anti-inflammatory activities compare to control and Indomethacin groups. KEY WORDS : Non-steroidal anti-inflammatory drugs, Mefenamic acid derivatives, Cyclooxygenase, Ear oedema test Bull. Chem. Soc. Ethiop. 2017 , 31(1), 171-175. DOI: http://dx.doi.org/10.4314/bcse.v31i1.15

Highlights

Non-steroidal anti-inflammatory drugs (NSAIDS) such as Ibuprofen, Mefenamic acid and selective cyclo-oxygenase-2 (COX-2) inhibitors are some of the most commonly prescribed medications worldwide, these drugs are used to treat painful inflammatory conditions such as arthritis, traumatic injuries, pain and fever [1]
Non-steroidal antiinflammatory drugs (NSAIDs) are among the most frequently prescribed drugs for treatment of pain, fever, and inflammatory and rheumatic diseases. Studies in this field, aimed at discovering better tolerated and potent NSAIDs with fewer side effects characteristic of current NSAIDs have been of interest for many years
The non-selective inhibition of the 2-isoforms of COX is considered to have been responsible for the unfavorable side effects associated with the chronic use of NSAIDs

Summary

Introduction

Non-steroidal anti-inflammatory drugs (NSAIDS) such as Ibuprofen, Mefenamic acid and selective cyclo-oxygenase-2 (COX-2) inhibitors are some of the most commonly prescribed medications worldwide, these drugs are used to treat painful inflammatory conditions such as arthritis, traumatic injuries, pain and fever [1]. The objective of this study, to synthesis new anti-inflammatory derivatives of Mefenamic acid as potential selective COX-2 inhibition with less ulcerogenic effect based on drug development.

Results

Conclusion