Abstract
In the present investigation we have synthesized a series of new 1‐[3‐(4‐substitutedphenyl)‐5‐phenyl‐4H‐1,2,4‐triazol‐4‐yl]urea and 1‐[3‐(4‐substitutedphenyl)‐5‐phenyl‐4H‐1,2,4‐triazol‐4‐yl]thiourea derivatives (4Ia ‐ 4IId). The newly synthesised derivatives were characterized by using the data of IR, 1H NMR and Mass Spectral analysis. Thus synthesised and characterized targetted compounds were further screened for their anti‐inflammatory activity by using Carrageenan – induced paw edema rat model. Among all the newly synthesized derivatives, Compounds 4Ia‐4Ic and Compounds 4IIa‐4IId were reduced the inflammation very significantly (p<0.0001), thus these compounds showed promising anti‐inflammatory activity and only one compound (4Id) showed moderate anti‐inflammatory activity (p<0.05).
Highlights
Among all the widely used therapeutic agents Nonsteroidal anti-inflammatory drugs (NSAIDs) primarily important for the treatment of inflammation and pain in arthritis. 1,2,4triazoles have long been known for their antiviral activity against the influenza 1 and HIV viruses 2–3
Triazoles were associated with central nervous4-6, antimicrobial7-9 activities.Various derivatives of 1,2,4-triazole have been reported to possess interesting biological activities such as hypoglycemic10 anti-inflammatory 11-13, antibacterial14, antifungal15, anticancer 16 analgesic17 and antidepressant activities18
Carrageenan - induced rat paw edema method21 was employed for evaluating the anti inflammatory activity of the synthesized compounds (4Ia-4IId)
Summary
Among all the widely used therapeutic agents Nonsteroidal anti-inflammatory drugs (NSAIDs) primarily important for the treatment of inflammation and pain in arthritis. 1,2,4triazoles have long been known for their antiviral activity against the influenza 1 and HIV viruses 2–3. Phenyl-4H-1,2,4-triazol-4-yl]urea and 1-[3-(4-substitutedphenyl)-5-phenyl-4H-1,2,4-triazol4-yl]thiourea derivatives as the targeted compounds as per the scheme-1 and evaluated for their anti-inflammatory activity. A mixture of compound (2) (0.01mol) and sodium acetate (0.02mol) were dissolved in 30 ml of glacial acetic acid with stirring. General procedure for the synthesis of 1-[3-(4-substitutedphenyl)-5-phenyl-4H-1,2,4-triazol4-yl]urea (4I)
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