Synthesis and Anti-inflammatory Action of (η-C 5H 5) 2 Ti(Sal) 2 and (η-C 5H 5) 2 Ti(Clo) 2

Abstract

Two new complexes (Cp) 2 Ti(Sal) 2 and (Cp) 2 Ti(Clo) 2 (Cp = Cyclopentadienyl η 5 -C 5 H 5 ), have been synthesized in anhydrous THF by the reaction of HSal( o -hydroxybenzoic acid, salicylate acid) or HClo[ N -( m -chloro-phenyl) anthraili acid, acidum clofenamicum] with (Cp) 2 TiCl 2 and characterized by means of elemental analyses, IR, 1 H NMR, 13 C NMR, UV and molar conductivity. In complex (Cp) 2 Ti(Sal) 2 or (Cp) 2 Ti(Clo) 2 , the oxygen atom of the carboxyl group coordinates to Ti(IV) in a monodentate manner. The inhibitory action of the complexes on mouse ear tumefaction caused by croton oil and rat foot granulation growth caused by cotton balls is higher than that of the corresponding ligands HSal, HClo and [(Cp) 2 TiCl 2 ], whereas their toxicity is lower than those of the free ligands.