Abstract
Dehydroabietic acid 5 was converted to the exocyclic olefin 7 by applying the Barton decarboxylation protocol. The latter served as key intermediate for the stereoselective synthesis of a variety of ring-A functionalized derivatives. Compounds 13 and 16 turned out to be active against the herpes virus (HSV-2) in the standard plaque assay and seem to interfere with an early event in viral replication.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
