Abstract
The steroids 7α,17β-dihydroxy-5α-androstan-3-one (7α-hydroxy-Dht), 5α-androstan-3α,7α,17β-triol (7α-hydroxy-3α-A'DIOL) and 5α-androstane-3β,7α,17β-triol (7α-hydroxy-3β-A'DIOL) have been synthetized from 7α,17β-dihydroxy-4-androsten-3-one (7α-hydroxy-testosterone). The effect of administering 7α-hydroxy-Dht, 7α-hydroxy-3α-A'DIOL or 7α-hydroxy-3β-A'DIOL on serum levels of LH, FSH, and on ventral prostate and seminal vesicle weight were investigated in gonadectomized adult male rats. Each steroid was administered for seven days in a dose of 300 μg per day. No suppression of serum LH or FSH levels was recorded following injections of these 7α-hydroxylated steroids to castrated rats, compared to castrated control rats receiving vehicle only. Administration of 7α-hydroxy-Dht or 7α-hydroxy-3α-A'DIOL to castrated mature rats could not maintain ventral prostate and seminal vesicle weights above that of castrated control rats. Administration of 7α-hydroxy-3β-A'DlOL to castrated mature rats resulted in ventral prostate weights slightly above castrate control levels, while seminal vesicle weight in such rats were in the same range as castrated control rats. Intraperitoneal administration of testosterone or of 5α-androstane-3β,17β-diol (3β-A'DIOL) to castrated rats maintained activity of the androgen dependent isoenzyme of acid phosphatase in the ventral prostate; 7α-hydroxy-testosterone or 7α-hydroxy-3β-A'DIOL showed, however, no effect on this enzymic activity.
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