Abstract
The preparation of molecularly imprinted microspheres for quercetin by aqueous suspension polymerization was first presented, in which quercetin is used as template molecule, methacrylic acid as functional monomer and ethylene glycol dimethacrylate as cross-linker. Morphological of the imprinted microspheres for quercetin was characterized by scanning electron microscopy. The imprinting effect of the imprinted microspheres was evaluated, and selectivity analysis suggests that the imprinted microspheres can selectively recognize quercetin from its structure analogues. In addition, adsorption kinetics and adsorption isotherm are used to investigate the binding characteristics of the imprinted microspheres. Results indicate that quercetin can be adsorbed rapidly by the imprinted microspheres, and the maximum theoretical static binding capacity is up to 96.5927 mg g-1.
Highlights
Quercetin (3,3’,4,5,7-penta-hydroxy flavone) is a plant-derived flavonoid found widely occurring in leaves, fruits, vegetables and grains [1]
There are a few reports about the preparation of Molecularly imprinted polymers (MIPs) for quercetin, but these MIPs were prepared by bulk polymerization followed by grinding to particles
The imprinted microspheres for quercetin were prepared by aqueous suspension polymerization, in which water solution containing 1.5% Polyvinyl alcohol (PVA) was used as continuous phase, and ethyl acetate solution was used as disperse phase
Summary
Quercetin (3,3’,4,5,7-penta-hydroxy flavone) is a plant-derived flavonoid found widely occurring in leaves, fruits, vegetables and grains [1]. Quercetin has become a hot topic based on its various bioactivities such as anti-inflammation, inoxidability, antiviral, antitumor and innate immune function [2]. The analysis of quercetin involve in HPLC-UV [3,4,5], electrogenerated chemiluminescence [6] and capillary electrophoresis [7]. Because of low concentrations of quercetins in nature, the complexity of samples and the structural similarity to other flavonols, selective extract methods are necessary prior to analysis. MIPs have been widely applied in drug separation, food and environmental testing, antibody or receptor analogues, sensors and many other fields, which have shown good prospects [11,12,13,14,15,16,17,18,19]
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