Abstract
Syntheses of four new pyrimidone analogues of the acetylcholinesterase (AChE) inhibitor huperzine A are reported together with the inhibitory potencies of these compounds for foetal bovine calf serum AChE; β-lactone formation followed by a thermal cycloreversion reaction serves as the key step for introduction of the ethylidene appendage of 12 in the stereochemically correct form.
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More From: Journal of the Chemical Society, Chemical Communications
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