Abstract

Abstract Trans-meranzinic acid, (+)-II, was synthesized from 2-hydroxy-4-methoxy-3-(3-methylbut-2-enyl)benzaldehyde (V) via (±)-2,3-dihydro-7-formyl-2-(1-hydroxy-1-methylethyl)-4-methoxybenzofuran (VII) and (±)-II which was successfully resolved by means of cinchonidine. Subsequently, (+)-II was subjected to exhaustive ozonolysis to afford known (+)-(R)-3-hydroxy-4,4-dimethylbutyrolactone (X). Thus, the stereochemistry of C-2 in (+)-II was assigned as R-configuration.

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