Abstract
Abstract The present work describes the synthesis of series of 3-(5- Substituted -1-benzofuran-2-yl)-1-(4-substituted phenyl)-1H-pyrazole-4-carbaldehyde derivatives (4a-4j) and (Z)-2-((3-(5- Substituted benzofuran-2-yl)-1-p-substituted -1H-pyrazol-4-yl) methylene)-2, 3-dihydro-5, 6-dimethoxyinden-1-one derivatives (5a-j). Among the synthesized compounds, 4a, 4d and 4 h and (5a-5j) were performed for preliminary screening of their analgesic and anti-inflammatory activities at a single dose of 100 mg/kg in mice by acetic acid induced writhing test and carrageenan-induced rat paw edema model respectively. Among the tested compounds, 5d, 5 g and 5 h were found to have higher analgesic activity with% of protection ranging from 50.49–60.53 and the compounds 4d, 4 h and 5d exhibited promising anti-inflammatory activity with% of protection 66.62–72.23.
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