Abstract
Synthesis, acaricidal activities and docking study of novel acrylonitrile derivatives
Highlights
The acrylonitrile group was a key skeleton in the insecticides, especially in acaricides, such as cyenopyrafen, SYP-9625
Synthesis and Spectra The synthetic route to the title acrylonitrile derivatives is shown in Scheme 1
The synthesized compounds were screened for their acaricidal activity against Tetranchus urticae
Summary
Plant fungal, weed and insect diseases can decrease productivity of crops in agriculture. 1-3 Pesticides can control many plant fungal and insect diseases effectively.[4,5,6] Mitochondria complex II (Succinate dehydrogenase, SDH) is an important target for pesticidal discovery.[5,6,7] To date, many small molecules[8,9,10,11,12,13,14,15,16,17,18,19,20] targeting SDH were discovered as fungicides and insecticides. Acrylonitrile compounds are attractive due to novel structures, low toxicity and high activity. The acaricidal activity was tested and a docking study was carried out.
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