Abstract

Abstract(−)‐Dehydrogriseofulvin (I) is converted to the diphenylether derivatives IV or VIII, respectively, by action of a base or an acid. The mechanism of the basic ring opening reaction has been established by use of 14C labelled methanol. In the case of the epimerisation of griseofulvin (II) under the influence of methylate, however, it is shown that a more complicated mechanism is involved.

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