Syntheses, structures, and inhibition studies of Jack bean urease by copper(II) complexes derived from a tridentate hydrazone ligand

Abstract

Urease inhibitors can counteract the negative effects of urease. In this paper, three new copper(II) complexes derived from 3-methyl-N′-(pyridin-2-ylmethylene)benzohydrazide (HL) were prepared. They are [CuBr(CH3OH)L] (1), [Cu(CH3OH)L(NCS)] (2), and [CuL(HL)]·ClO4 (3). The complexes were characterized by infrared and UV–Vis spectra, and single crystal X-ray determination. The Cu atoms in complexes 1 and 2 display square pyramidal coordination, and in complex 3 the Cu atom displays octahedral coordination. Complex 1 shows effective urease inhibitory activity, with IC50 value of 1.46±0.83μM. Molecular docking study of the complexes with Jack bean urease was performed.