Abstract
Two types of poly-deuterated isocarbacyclin [9(O)-methano-Δ6(9α)-prostaglandin I1] methyl ester have been synthesized for the use of GC-MS quantitative analysis as internal standards and for the use of metabolic study as substrates. The 5,13,14-2H3 derivative 2 was prepared via H-D exchange, deuteroboration, and sodium borodeuteride reduction. The 2,2,3,3,4,4-2H6 derivatives 3, 4 were prepared starting from tetrahydrofuran-d8.
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