Syntheses of N-Acyl Derivatives of α-Methyl-3, 4-methylenedioxyphenethylamine and their Analgesic Activity.

Abstract

Several acids- and aminoacids-derivatives of α-methyl-3, 4-methylenedioxyphenethylamine were synthesized and their analgesic activities in mice were estimated by two methods. The most potent compound was propionamide of the amine (SA-8) and this was 1.4 times more potent than aminopyrine. SA-8 was sedative in mice, and it markedly augmented the hypnotic action of hexobarbital.