Abstract
The target molecules are angiogenesis inhibitors except FR65814, which is an immunosuppressant. Noteworthy features of this synthesis include (1) the l-proline-catalyzed enantioselective α-aminoxylation reaction (see Y. Hayashi et al. Angew. Chem. Int. Ed. 2004, 43, 1112-1115 and Tetrahedron Lett. 2003, 44, 8293-8296), and (2) the hydroxyl-directed conjugate addition of an organozinc species. The syntheses of Ovalicin and 5-Demethylovalicin are also described.
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