Abstract
Coordination compounds of 2-amino-3-methylbutanoic acid were synthesized with chromium(III) and oxovanadium(IV) ions. M:L; 1:2. Adducts of these complexes using 1,10-phenantroline and ethylenediamine were further synthesized, M:L, (1:2). These compounds were characterized using electronic, infra-red spectrophotometry, magnetic susceptibility measurement and percentage metal analyses. The zones of inhibition and minimum inhibitory concentrations of the compounds against eight microbes were studied. The results obtained indicated an octahedral geometry for the Cr(III) complexes, indicative of additional coordination of two water molecules. On the other hand a square pyramid geometry was obtained for the binary oxovanadium complex and its 1,10-phenantroline adduct. However, for the oxovanadium ethylenediamine adduct a distorted octahedral geometry was proposed. The result for the antibacterial studies indicated that both mixed ligand complexes of 1,10-phenantroline exhibited good antibacterial activity, and in some cases better activity than the standard, streptomycin.
Highlights
Coordination compounds of 2-amino-3-methylbutanoic acid were synthesized with chromium(III) and oxovanadium(IV) ions
Coordination compounds of 2-amino-3-methylbutanoic acid and its 1,10-phenantroline and ethylenediamine adducts were synthesized with chromium(III) and oxovanadium(IV) ions
The results obtained suggested an octahedral geometry for all the chromium(III) complexes
Summary
The pharmacological activity of these metal compounds depends on the metal ion, ligands and the structure of the compounds. These factors are partly responsible for the ability of these coordination compounds, to locate the proper target site of activity and as a consequence their pharmacological activity [1] [2] [3] [4]. Prior reports have indicated that the efficacies of various therapeutic agents are often enhanced upon coordination with a suitable metal ion [7] [8] [9]
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