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Abstract
A convenient method for the syntheses of non‐1‐ynitols 8a–8d, by chemoselective addition of (trimethylsilyl)‐propargylmagnesium bromide at the anomeric center of a 1‐unprotected sugar, in the presence of 3‐C′‐halide and 3‐C′‐silyl functions in the side chain is described. In addition, an efficient method for the synthesis of 3‐C′‐hydroxymethyl sugar 3 via the addition of C1 silyl Grignard reagents to ulose 1 and subsequent oxidation by the Fleming‐Tamao method in excellent yields is reported. Also, a suitable acid‐catalyzed isomerization of the 1,2‐O‐isopropylidene group to the 2,3‐O‐isopropylidene group (5a–5f), to get access to the anomeric center, in good to excellent yields has been depicted.
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