Abstract
In order to obtain an effective analgesic agent, 4-amino-3-methyl-1, 2-diphenylbutane derivatives were synthesized. These compounds, the structure of which are similar to propoxyphene, have hydroxyl, methoxyl, benzyloxyl, or acyloxy group in the benzene ring and dimethylamino, 1-piperidino, diallylamino, or benzylamino group as a basic function. Further, two kinds of diastereoisomers were separated by column chromatography or fractional crystallization. Structure of these compounds was confirmed by spectral data.
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