Syntheses, Crystal Structures, and Spectroscopic Studies of Aromatic Ester Derivatives of Hexamolybdate

Abstract

AbstractTwo new hybrids of local anesthetic analogs and polyoxometalates {(Bu4N)2[Mo6O18NC6H4COOCH3] (1) and (Bu4N)2[Mo6O18NC6H4COOC2H5] (2)} have been prepared in high purity and moderate yields using the easy reaction route of [α‐Mo8O26]4– with corresponding aromatic amine hydrochlorides in the presence of a N,N′‐dicyclohexylcarbodiimide (DCC), and have been characterized by 1H NMR, IR, UV/Vis, ESI‐MS, and single‐crystal X‐ray diffraction study. Compound 1 crystallizes in the triclinic space group P$\bar {1}$ with dimer structure, while Compound 2 crystallizes in the monoclinic space group P21/n with dimer and chain structure. These two hybrids have the typical Mo≡N triple bond that links a phenylimido group in local anesthetic analogs to the Mo atom of a hexamolybdate cluster. Because the formed Mo≡N bond is not stable in basic solution, this property is useful and could be developed as a novel controlled‐release technology for drug delivery.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)