Syntheses, characterizations, crystal structures, and in vitro antitumor activities of chiral triorganotin(IV) complexes containing (S)-(+)-2-(4-isobutyl-phenyl)propionic and (R)-(+)-2-(4-hydroxyphenoxy)propionic acid ligands

Abstract

Four new chiral triorganotin(IV) carboxylates, [(R3Sn)(O2C13H17)] n (R = Me 1, Ph 2), [(R3Sn)(O2C13H17)] (R = n-Bu 3), and [(R3Sn)(O4C9H9)] n (R = Me 4), have been synthesized by reaction of (S)-(+)-2-(4-isobutyl-phenyl)propionic acid and (R)-(+)-2-(4hydroxyphenoxy)propionic acid with triorganotin(IV) chloride in the presence of sodium ethoxide. The complexes have been characterized by elemental analyses, FT-IR, NMR (1H, 13C, and 119Sn) spectra, and X-ray crystallography diffraction analyses. Structural analyses show that 1 has a 1-D infinite chiral zigzag chain structure. Complexes 2 and 4 have a 1-D spring-like chiral helical chain with a channel, while 3 is a monomer. Antitumor activities of 1–4 have been studied.