Abstract
Two novel Cu(II) complexes, [Cu(L)2(CH3OH)]·CH3OH (1) and [Cu(L)(DMF)Cl] (2) based on HL (where HL=2-ethoxycarbonyl-5-formyl-3,4-dimethylpyrrole 4-hydroxylbenzoylhydrazone) were synthesized and characterized by X-ray diffraction analyses. The results show that in each complex, the acylhydrazone ligand is deprotonated and coordinated to the copper(II) ion via enolizated oxygen and imine nitrogen atoms. The central metal ion possesses a distorted square pyramidal and a square-planar coordination geometry in complexes 1 and 2, respectively. In addition, complex 2 shows obvious inhibitory effect to bacterial strains Staphylococcus aureus and Salmonella typhimurium, and complex 1 has excellent antitumor activity towards Hepatocellular carcinoma (Hep G2) cells (IC50=2.0μM).
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