Syntheses, characterization, crystal structures and Jack bean urease inhibitory activities of ZnII, CoII/III and NiII complexes derived from reduced Schiff base ligand

Abstract

A series of new ZnII, CoII/III and NiII complexes derived from reduced Schiff base 6,6′-((propane-1,3-diylbis(azanediyl))bis(methylene))bis(2-ethoxyphenol) (H2L), [Zn3L2(N3)2] (1), [Co2L(N3)2(CH3COO)]·CH3OH (2) and [Ni(HL)(OH2)(CH3OH)]·ClO4 (3), were prepared and characterized by physico-chemical methods. Crystal structures of the complexes were determined by single crystal X-ray diffraction. Complex 1 is a trinuclear zinc(II) compound. Complex 2 is a dinuclear cobalt(II/III) compound. Complex 3 is a mononuclear nickel(II) compound. The cobalt complex and the nickel complex have effective urease inhibitory activities, with IC50 values of 19.8 and 11.6 μmol·L−1, respectively. However, the zinc complex 1 has no such activity. Molecular docking study of complexes 2 and 3 with the active center of Jack bean urease was studied.