Abstract
Five new dinuclear silver(I) complexes, namely [Ag2(μ-4-Cl-pz)2(PPh3)4] (1), [Ag2(μ-4-Cl-pz)2(PPh3)3] (2), [Ag2(μ-4-NO2-pz)2(PPh3)4] (3), [Ag2(μ-4-NO2-pz)2(PPh3)3] (4) and [Ag2(μ-4-Cl-pz)2(PTA)4] (5) (where pz = pyrazolate and PTA = 1, 3, 5-triazaphosphaadamantane) have been synthesized and structurally characterized. The coordination geometry of both silver centers in complexes 1, 3 and 5 is distorted tetrahedral, while in case of complexes 2 and 4, one of the Ag centers resides in a trigonal planar environment. The two μ-pyrazolates act as bridges between two Ag atoms. Complex 5 is highly soluble in water and exhibits strong antimicrobial actions against a Gram-negative nosocomial pathogen Pseudomonas aeruginosa. The zone of bacterial clearance by complex 5 in SSTI (soft tissue and skin infection) model is found to be comparable to that by silver nitrate.
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