Syntheses and structural studies of platinum(II) complexes of O-methylselenomethionine and related ligands

Michael Carland,Brendan F Abrahams,Teresa Rede,Jodie Stephenson,Vincent Murray,William A Denny,W David Mcfadyen

doi:10.1016/j.ica.2006.03.008

Syntheses and structural studies of platinum(II) complexes of O-methylselenomethionine and related ligands

Michael Carland, Brendan F Abrahams + Show 5 more

https://doi.org/10.1016/j.ica.2006.03.008

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Journal: Inorganica Chimica Acta	Publication Date: Mar 20, 2006
Citations: 15

Affiliation: UNSW Sydney, University of Melbourne, Cancer Society of New Zealand, University of Auckland

#Cis Chloride Ligands #Structure Of Dichloro + Show 8 more

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Abstract

The complexes dichloro[2-(phenylselanyl)ethanamine]platinum(II), dichloro[2-(benzylselanyl)ethanamine]platinum(II) and dichloro( O-methylselenomethionine)platinum(II) have been prepared and the structure of dichloro( O-methylselenomethionine)platinum(II) has been determined by single crystal X-ray diffraction. The Pt(II) is in a square planar environment and is coordinated by two cis chloride ligands and a chelating O-methylselenomethionine ligand. The cytotoxicities of the compounds have been assessed in the human cell lines HeLa and K562 and they are at least threefold less toxic than cisplatin in both cell lines.

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