Abstract
Nine novel symmetrical and asymmetrical 2,5-disubstituted 1,3,4-oxadiazoles have been synthesized by a facile and mild method with high yield. Meantime, it was found that the fluorine was easy substituted by hydrazine in polyhalogen-substituted aroyl hydrazine. The preliminary bioassay tests show that two of the compounds ( D5 and D6) exhibited a significant insecticidal activity (LC 50=116.02 and 70.93 mg l −1) on armyworm, Leucania separata Walker. Using the Drug Discovery Workbench (DDW) (Cerius 2), structure–activities relationship was studied.
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