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Abstract
Ketals, hemithioketals, and dithioketals of nuclear-substituted styryl ketones were prepared as latentiated forms of the ketones. This undertaking was based on the premise that there is increased acidity in tumors compared to normal tissue, and thus preferential regeneration of the ketone in neoplastic tissue may occur. Attempts to form 1,3-dioxolans of Mannich bases were unsuccessful. The prepared compounds did not possess significant anticancer properties, but analgesic, anti-inflammatory, antihistaminic, and antimicrobial activities were found in the prepared Mannich bases.
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