Abstract
Abstract The title compounds were prepared employing the regioselective cycloaddition of the (+)-naphthoquinone derivative, the CDEF-ring system of nogalamycin, with various homophthalic anhydrides. Among the 7-methoxylnogarene derivatives obtained, 7-methoxy- and 9-hydroxy-7-methoxy-9-demethylnogarene and their 2′,4′-diacetates were found to show prominent in vitro cytotoxicity against P388 murine leukemia.
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