Abstract
Abstract Three new ethyltin complexes containing ferrocenecarboxylate, Et2Sn(OC(O)Fc)2 (1), [(Et2SnOC(O)Fc)2O]2 (2), and [EtSn(O)OC(O)Fc]6 (3) (Fc = C5H5FeC5H4), have been synthesized by the reaction of diethyltin dichloride with ferrocenecarboxylic acid in the presence of potassium hydroxide and characterized by means of elemental analysis, FT-IR, NMR spectroscopy, and X-ray single crystal diffraction. In solid state, 1 is a weak dimer possessing a cyclic Sn2O2 unit formed by the intermolecular Sn⋯O interaction, and the tin atom has a distorted pentagonal bipyramid geometry. Compound 2 is a four-tin nuclear diethyltin complex with a ladder framework, and each tin atom adopts a distorted trigonal bipyramidal configuration in which two oxygen atoms occupy the axial positions. Compound 3 is a hexa-tin nuclear monoethyltin complex having a drum-shaped structure, and each of the tin atoms possesses a distorted octahedral geometry. The ferrocene units are attached to the tin atoms through the monodentate or bidentate coordinated carboxylates.
Highlights
Organotins are a kind of widely used main group metal compound, which have more applications than the organic derivatives of any other metal (Davies et al, 2008)
To synthesize organotin carboxylates containing ferrocenyl group is a valuable choice for broadening the use of ferrocene derivatives and searching for highly efficient and low toxic organotin anticancer drugs
Some organotin carboxylates containing ferrocenyl were synthesized in succession and showed good in vitro anticancer activity
Summary
Organotins are a kind of widely used main group metal compound, which have more applications than the organic derivatives of any other metal (Davies et al, 2008). They have been used as stabilizers for polyvinyl chloride, ionophores in sensors, insecticides, fungicides, organic synthesis reagents, reaction catalysts, and so on (Davies et al, 2008). To synthesize organotin carboxylates containing ferrocenyl group is a valuable choice for broadening the use of ferrocene derivatives and searching for highly efficient and low toxic organotin anticancer drugs. Some organotin carboxylates containing ferrocenyl were synthesized in succession and showed good in vitro anticancer activity. In order to continue to expand the chemistry of the ferrocene–organotin compounds, we synthesized three ethyltin ferrocenecarboxylates, Et2Sn(OC(O)Fc) (1), [(Et2SnOC(O)Fc)2O]2 (2), and [EtSn(O)OC(O)Fc]6 (3), and determined their crystal structures (Scheme 1)
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