Abstract
To build V-shaped symmetrical structure thiadiazole derivatives,isophthalic acid and 5-aminoisophthalic acid condensed with 3-aliphatic-1,2,4-triazole( 1) respectively. In POCl3 presence,fourteen symmetrical V-shaped triazolo-thiadiazole derivatives( 2a—2g and 3a—3g) were synthesized,wherein thirteen of them were first synthesized,and the structures of compounds 2 and 3 were characterized by infrared( IR),nuclear magnetic resonance( NMR) and high resolution mass spectrometer( HRMS). The inhibitory activities of the target compounds were screened for Cdc25 B and PTP1 B. The results showed that some compouds exhibited inhibitory activities against Cdc25 B,compounds 3b and 3f may be used as potential Cdc25 B inhibitors in the treatment of cancer. Compouds 3b—3g exhibited inhibitory activities against PTP1 B. Compounds 3b and 3e may be used as potential PTP1 B inhibitors in the treatment of diabetes.
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