Syntheses and anti-tumor activity of N-heterocyclic compounds having the cyclic hydrazide structure (author's transl)

Abstract

Compounds possessing a cyclic hydrazide structure in their molecule, 2-amino-3-phenyl-1 (2H)-isoquinolinone (I1), 3-amino-2-(4-methoxyphenyl)-4 (3H)-quinazolinone (II1), 5-amino-1, 5-dihydro-1-phenyl-4H-pyrazolo [3, 4-d] pyrimidin-4-one (III1), 5-amino-1, 5-dihydro-1-(2-pyridyl)-4H-pyrazolo [3, 4-d] pyrimidin-4-one (IV1), and 30 kinds of their derivatives were synthesized for antitumor screening. It was found that 5-(benzoylamino)-1, 5-dihydro-1-phenyl-4H-pyrazolo [3, 4-d] pyrimidin-4-one (III5) possessed an anti-tumor activity against Sarcoma-180A.