Synthese von selektiv N‐ funktionalisierten Polyamin‐Derivaten

Abstract

Synthesis of Selectively N‐Functionalized Polyamine DerivativesA threefold differently protected derivative 8 of the triamine spermidine (2) has been prepared in three steps starting from propane‐1,3‐diamine (1). The protected spermidine derivative 8 was converted to its spermine analogue 12, a useful polyamine intermediate. In a convergent way, the fourfold differently protected derivative 18 of the tetraamine spermine (3) has been obtained by coupling the two different and separately prepared propane‐1,3‐diamine units 15 and 17. Spermidine derivative 19 and spermine derivative 20, both selectively protected at both primary amino groups, have been Prepared from the free polyamines 2 and 3, respectively, in a direct approach.