Synthese Eines Optisch Aktiven Penem‐Zwischenprodukts Mittels Asymmetrischer Amidoalkylierung

Abstract

Synthesis of an Optically Active Penem Intermediate by Asymmetric AmidoalkylationThe amidoalkylation of an optically active, cationic glycine derivative with methyl acetoacetate furnishes an intermediate 10a (Scheme 2) that is transformed in six steps to the optically active, silyl‐protected 4‐acetoxy‐3‐(1‐hydroxyenthyl)‐2‐azetidinon 18a, a well known intermediate in penem synthesis.