Abstract
The aminodisaccharide glycoside methyl 2,4-diamino-2,4-dideoxy-6- O-(2,6-diamino-2,6-dideoxy-α- d-glucopyranosyl)-β- d-glucopyranoside ( 4), which exhibits a structural resemblance to neamine, was synthesized via the azido method. Starting from 6- O-acetyl-2-azido-3,4-di- O-benzyl-2-deoxy-α- d-glucopyranosyl bromide, the α- d-glycosylation of O-6 of methyl 2,4-diazido-3- O-benzyl-2,4-dideoxy-β- d-glucopyranoside was accomplished stereoselectively at low temperatures in the presence of mercury bromide. Against some gram-negative test-organisms, the activity of 4 was found to be in the same range as neamine, but directed against different germs.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
