Synthese De Phospholipides Marques Au Carbone 14 A l'aide Du “pyrophosphate D'Enediol Cyclique”

Abstract

Abstract14C labelled phospholipid synthesis through the use of “cyclic enediolpyrophosphate”.Ramirez's phrophosphate 1 was used in a one pot convenient synthesis of a few [1‐14C]‐acyl phospholipids. Reagent 1 was condensed with 1,2‐[1‐14C] dipalmitoyl Sn‐glycerol to the cyclic triester phosphate 4 which without isolation, was reacted with N‐tritylethanolamine, 3‐0‐benzyl Sn‐glycerol and glycerol leading to intermediates 5, 6, 7 which were deprotected by triethylamine hydrolysis and other appropriate treatments.