SYNTAX score as predictor of one-year mortality in patients with NSTE-ACS

Abstract

The syntax score have been used as surrogate end-points for evaluating the complexity of coronary lesions in stable coronary artery disease, but their predictive value in acute coronary artery disease is inconclusive. The aim of this study was to evaluate the ability of the syntax score to predict one-year mortality in patients with NSTE-ACS. Patients admitted for NSTE-ACS and indication for coronary angiography were prospectively evaluated. The Syntax score was calculated. A ROC curve was developed to define the Syntax score cut-off that best predicts one-year cardiovascular mortality. A total of 296 patients were evaluated: mean age was 62 ± 12 years and 58% were male. The cardiovascular one-year mortality was 5.4% (16 patients). The syntax score in these patients was significantly higher (31.3 ± 13.3 vs. 13.1 ± 13.2; p < 10 −3 ). Syntax score ≥ 20 showed a sensitivity of 87.5%, specificity of 75.7%. The area under the ROC curve was 0.84 (95% confidence interval of 0.76–0.93) ( Fig. 1 ). Syntax score ≥ 20 had a good specificity to predict one-year mortality in patients with NSTE-ACS. Its measurement may be incorporated to help in the assessment and stratification of NSTE-ACS patients.