Abstract
A 49-year-old Japanese man presented witha painful mass on his right calf that was foundby histopathologic and immunohistochemical anal-yses of an open biopsy specimen to be a synovialsarcoma of the monophasic fibrous type. An SYT-SSX1 fusion gene, resulting from the chromosomaltranslocation of t(x;18)(p11.2;q11.2) was detected byreverse transcription polymerase chain reaction.After amputation of his right leg, the patientunderwent chemotherapy and radiotherapy to treatlung metastases. Subsequently, he developed me-lena and was found to be anemic. Upper endoscopydemonstrated multiple protruding lesions with acentral depression in the stomach and duodenum(A,B,C).Freshclotwasattachedtooneofthelesions.Biopsy specimens from one of the gastric lesionsrevealed spindle cell proliferation in the mucosa(D, H&E, orig. mag. 333) that was similar to thesynovial sarcoma from the right calf.
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