Abstract

Purpose: Synovitis plays an important role in the pathogenesis of arthritis. Our objective was to differentiate the inflammatory phenotypes of osteoarthritis (OA) and rheumatoid arthritis (RA) synovium through single-cell RNA sequencing (scRNA-seq) and to test and validate the methodology by using bulk-RNA-seq data to create in silico scRNA-seq data for synovial tissue.

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