Abstract
Purpose: Knee osteoarthritis (OA) is characterized by progressive joint damage, including cartilage degradation, bone remodeling, subchondral bone sclerosis, and synovitis. Knee joints are densely innervated by sensory afferents, mostly pain-sensing neurons (nociceptors). We previously reported that the intra-articular nociceptive innervation of the medial compartment of the murine knee joint displays profound neuroplasticity 16 weeks after destabilization of the medial meniscus (DMM). In particular, we observed sprouting of nociceptors in the medial synovium and meniscus, as well as NaV1.8+ nociceptors in subchondral bone channels, closely recapitulating what has been described in human knees with late-stage OA.
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