Abstract
Mecillinam was combined with ampicillin, carbenicillin, cloxacillin, and cefalexin and tested in vitro against clinical isolates of gram-negative bacteria. Synergy was frequently found, but test medium and inoculum size affected the extent of synergy. No synergy was obtained for combinations between mecillinam and penicillins against β-lactamase-producingHaemophilus influenzae orNeisseria gonorrhoeae, while combinations of clavulanic acid and penicillins showed strong synergism. Strains resistant to mecillinam were cultured in vitro, but the development of resistance was slower for the combinations than for mecillinam itself.
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